Topical and Transdermal Therapies for Symptom Palliation: Utility, Limitations and Future Opportunities

In this seminar we will explore the rationale, opportunities and limitations of the cutaneous application of medications for symptom management.  The evidence base bearing upon those medications and preparations most commonly used “topically” will be reviewed, their strengths and limitations highlighted and research opportunities explored.  Special attention will be given to the treatment of the varied conditions of cutaneous pain and the potential value of topical analgesia in these settings. Although the emphasis will be on practical clinical therapeutics, supported by illustrative case examples, basic foundational concepts will also be explored including a brief review of the anatomy and physiology of the skin and the potential barriers posed to transcutaneous medication delivery.   Finally, investigational approaches to optimizing this route of medication delivery will be explored.